Protocol for a prospective interventional trial to develop a diagnostic index test for stroke as a cause of vertigo, dizziness and imbalance in the emergency room (EMVERT study).
Identifieur interne : 000515 ( Main/Exploration ); précédent : 000514; suivant : 000516Protocol for a prospective interventional trial to develop a diagnostic index test for stroke as a cause of vertigo, dizziness and imbalance in the emergency room (EMVERT study).
Auteurs : Ken Möhwald [Allemagne] ; Stanislavs Bardins [Allemagne] ; Hans-Helge Müller [Allemagne] ; Klaus Jahn [Allemagne] ; Andreas Zwergal [Allemagne]Source :
- BMJ open [ 2044-6055 ] ; 2017.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (complications), Accident vasculaire cérébral (diagnostic), Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (MeSH), Diagnostic différentiel (MeSH), Diplopie (diagnostic), Diplopie (étiologie), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Imagerie par résonance magnétique (méthodes), Jeune adulte (MeSH), Mâle (MeSH), Neurologie (MeSH), Plan de recherche (MeSH), Sensation vertigineuse (diagnostic), Sensation vertigineuse (étiologie), Sensibilité et spécificité (MeSH), Service hospitalier d'urgences (MeSH), Sujet âgé (MeSH), Vertige (diagnostic), Vertige (étiologie), Équilibre postural (MeSH), Études prospectives (MeSH).
- MESH :
- diagnostic : Accident vasculaire cérébral, Diplopie, Sensation vertigineuse, Vertige.
- méthodes : Imagerie par résonance magnétique.
- étiologie : Diplopie, Sensation vertigineuse, Vertige.
- complications : Accident vasculaire cérébral, Adulte, Adulte d'âge moyen, Allemagne, Diagnostic différentiel, Facteurs de risque, Femelle, Humains, Jeune adulte, Mâle, Neurologie, Plan de recherche, Sensibilité et spécificité, Service hospitalier d'urgences, Sujet âgé, Équilibre postural, Études prospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Diagnosis, Differential (MeSH), Diplopia (diagnosis), Diplopia (etiology), Dizziness (diagnosis), Dizziness (etiology), Emergency Service, Hospital (MeSH), Female (MeSH), Germany (MeSH), Humans (MeSH), Magnetic Resonance Imaging (methods), Male (MeSH), Middle Aged (MeSH), Neurology (MeSH), Postural Balance (MeSH), Prospective Studies (MeSH), Research Design (MeSH), Risk Factors (MeSH), Sensitivity and Specificity (MeSH), Stroke (complications), Stroke (diagnosis), Vertigo (diagnosis), Vertigo (etiology), Young Adult (MeSH).
- MESH :
- complications : Stroke.
- diagnosis : Diplopia, Dizziness, Stroke, Vertigo.
- etiology : Diplopia, Dizziness, Vertigo.
- methods : Magnetic Resonance Imaging.
- Adult, Aged, Diagnosis, Differential, Emergency Service, Hospital, Female, Germany, Humans, Male, Middle Aged, Neurology, Postural Balance, Prospective Studies, Research Design, Risk Factors, Sensitivity and Specificity, Young Adult.
Abstract
INTRODUCTION
Identifying stroke as a cause of acute vertigo, dizziness and imbalance in the emergency room is still a clinical challenge. Many patients are admitted to stroke units, but only a minority will have strokes. This imposes a heavy financial burden on the healthcare system. The aim of this study is to develop a diagnostic index test to identify patients with a high risk of having a stroke as the cause of acute vertigo and imbalance.
METHODS AND ANALYSIS
Patients with acute onset of vertigo, dizziness, postural imbalance or double vision within the last 24 hours lasting for at least 10 min are eligible to be included in the study. Patients with clinically proven peripheral or central aetiology will be excluded. In the emergency room, all enrolled patients will undergo standardised neuro-ophthalmological/physiological testing (including video-oculography, mobile posturography, measurement of subjective visual vertical) (EMVERT block 1). Within 10 days, standardised MRI will be performed as a reference test to identify stroke (EMVERT block 2). Data from EMVERT block 2 will be compared with results from block 1 in order to devise a diagnostic index test with a high specificity and sensitivity to predict the risk of stroke in the emergency room.
ETHICS AND DISSEMINATION
The study was approved by the ethics committee of the University of Munich and will be conducted according to the Guideline for Good Clinical Practice, the Federal Data Protecting Act and the Helsinki Declaration of the World Medical Association in its recent version. Study results are expected to be published in international peer-reviewed journals and will be presented at international conferences.
TRIAL REGISTRATION NUMBER
German Clinical Trial Register: DRKS00008992; Universal trial number: U1111-1172-8719); pre-results.
DOI: 10.1136/bmjopen-2017-019073
PubMed: 29018076
PubMed Central: PMC5652468
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Bardins, Stanislavs" sort="Bardins, Stanislavs" uniqKey="Bardins S" first="Stanislavs" last="Bardins">Stanislavs Bardins</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muller, Hans Helge" sort="Muller, Hans Helge" uniqKey="Muller H" first="Hans-Helge" last="Müller">Hans-Helge Müller</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Jahn, Klaus" sort="Jahn, Klaus" uniqKey="Jahn K" first="Klaus" last="Jahn">Klaus Jahn</name><affiliation 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sortKey="Zwergal, Andreas" sort="Zwergal, Andreas" uniqKey="Zwergal A" first="Andreas" last="Zwergal">Andreas Zwergal</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Diagnosis, Differential (MeSH)</term><term>Diplopia (diagnosis)</term><term>Diplopia (etiology)</term><term>Dizziness (diagnosis)</term><term>Dizziness (etiology)</term><term>Emergency Service, Hospital (MeSH)</term><term>Female (MeSH)</term><term>Germany (MeSH)</term><term>Humans (MeSH)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neurology (MeSH)</term><term>Postural Balance (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Research Design (MeSH)</term><term>Risk Factors (MeSH)</term><term>Sensitivity and Specificity (MeSH)</term><term>Stroke (complications)</term><term>Stroke (diagnosis)</term><term>Vertigo (diagnosis)</term><term>Vertigo (etiology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (complications)</term><term>Accident vasculaire cérébral (diagnostic)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (MeSH)</term><term>Diagnostic différentiel (MeSH)</term><term>Diplopie (diagnostic)</term><term>Diplopie (étiologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (méthodes)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Neurologie (MeSH)</term><term>Plan de recherche (MeSH)</term><term>Sensation vertigineuse (diagnostic)</term><term>Sensation vertigineuse (étiologie)</term><term>Sensibilité et spécificité (MeSH)</term><term>Service hospitalier d'urgences (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Vertige (diagnostic)</term><term>Vertige (étiologie)</term><term>Équilibre postural (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Diplopia</term><term>Dizziness</term><term>Stroke</term><term>Vertigo</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Diplopie</term><term>Sensation vertigineuse</term><term>Vertige</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Diplopia</term><term>Dizziness</term><term>Vertigo</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Imagerie par résonance magnétique</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Diplopie</term><term>Sensation vertigineuse</term><term>Vertige</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Emergency Service, Hospital</term><term>Female</term><term>Germany</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurology</term><term>Postural Balance</term><term>Prospective Studies</term><term>Research Design</term><term>Risk Factors</term><term>Sensitivity and Specificity</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allemagne</term><term>Diagnostic différentiel</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Neurologie</term><term>Plan de recherche</term><term>Sensibilité et spécificité</term><term>Service hospitalier d'urgences</term><term>Sujet âgé</term><term>Équilibre postural</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Identifying stroke as a cause of acute vertigo, dizziness and imbalance in the emergency room is still a clinical challenge. Many patients are admitted to stroke units, but only a minority will have strokes. This imposes a heavy financial burden on the healthcare system. The aim of this study is to develop a diagnostic index test to identify patients with a high risk of having a stroke as the cause of acute vertigo and imbalance.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND ANALYSIS</b></p><p>Patients with acute onset of vertigo, dizziness, postural imbalance or double vision within the last 24 hours lasting for at least 10 min are eligible to be included in the study. Patients with clinically proven peripheral or central aetiology will be excluded. In the emergency room, all enrolled patients will undergo standardised neuro-ophthalmological/physiological testing (including video-oculography, mobile posturography, measurement of subjective visual vertical) (EMVERT block 1). Within 10 days, standardised MRI will be performed as a reference test to identify stroke (EMVERT block 2). Data from EMVERT block 2 will be compared with results from block 1 in order to devise a diagnostic index test with a high specificity and sensitivity to predict the risk of stroke in the emergency room.</p></div><div type="abstract" xml:lang="en"><p><b>ETHICS AND DISSEMINATION</b></p><p>The study was approved by the ethics committee of the University of Munich and will be conducted according to the Guideline for Good Clinical Practice, the Federal Data Protecting Act and the Helsinki Declaration of the World Medical Association in its recent version. Study results are expected to be published in international peer-reviewed journals and will be presented at international conferences.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION NUMBER</b></p><p>German Clinical Trial Register: DRKS00008992; Universal trial number: U1111-1172-8719); pre-results.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29018076</PMID><DateCompleted><Year>2018</Year><Month>06</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>10</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>10</Day></PubDate></JournalIssue><Title>BMJ open</Title><ISOAbbreviation>BMJ Open</ISOAbbreviation></Journal><ArticleTitle>Protocol for a prospective interventional trial to develop a diagnostic index test for stroke as a cause of vertigo, dizziness and imbalance in the emergency room (EMVERT study).</ArticleTitle><Pagination><MedlinePgn>e019073</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2017-019073</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Identifying stroke as a cause of acute vertigo, dizziness and imbalance in the emergency room is still a clinical challenge. Many patients are admitted to stroke units, but only a minority will have strokes. This imposes a heavy financial burden on the healthcare system. The aim of this study is to develop a diagnostic index test to identify patients with a high risk of having a stroke as the cause of acute vertigo and imbalance.</AbstractText><AbstractText Label="METHODS AND ANALYSIS" NlmCategory="UNASSIGNED">Patients with acute onset of vertigo, dizziness, postural imbalance or double vision within the last 24 hours lasting for at least 10 min are eligible to be included in the study. Patients with clinically proven peripheral or central aetiology will be excluded. In the emergency room, all enrolled patients will undergo standardised neuro-ophthalmological/physiological testing (including video-oculography, mobile posturography, measurement of subjective visual vertical) (EMVERT block 1). Within 10 days, standardised MRI will be performed as a reference test to identify stroke (EMVERT block 2). Data from EMVERT block 2 will be compared with results from block 1 in order to devise a diagnostic index test with a high specificity and sensitivity to predict the risk of stroke in the emergency room.</AbstractText><AbstractText Label="ETHICS AND DISSEMINATION" NlmCategory="UNASSIGNED">The study was approved by the ethics committee of the University of Munich and will be conducted according to the Guideline for Good Clinical Practice, the Federal Data Protecting Act and the Helsinki Declaration of the World Medical Association in its recent version. Study results are expected to be published in international peer-reviewed journals and will be presented at international conferences.</AbstractText><AbstractText Label="TRIAL REGISTRATION NUMBER" NlmCategory="BACKGROUND">German Clinical Trial Register: DRKS00008992; Universal trial number: U1111-1172-8719); pre-results.</AbstractText><CopyrightInformation>© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Möhwald</LastName><ForeName>Ken</ForeName><Initials>K</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3112-2134</Identifier><AffiliationInfo><Affiliation>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardins</LastName><ForeName>Stanislavs</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Hans-Helge</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahn</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neurology, Schön Klinik, Bad Aibling, Bad Aibling, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zwergal</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>German Center for Vertigo and Balance Disorders, DSGZ, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMJ Open</MedlineTA><NlmUniqueID>101552874</NlmUniqueID><ISSNLinking>2044-6055</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004172" MajorTopicYN="N">Diplopia</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004244" MajorTopicYN="N">Dizziness</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004636" MajorTopicYN="Y">Emergency Service, Hospital</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009462" MajorTopicYN="N">Neurology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="Y">Postural Balance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012107" MajorTopicYN="N">Research Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014717" MajorTopicYN="N">Vertigo</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">dizziness</Keyword><Keyword MajorTopicYN="N">emergency medicine</Keyword><Keyword MajorTopicYN="N">magnetic resonance imaging</Keyword><Keyword MajorTopicYN="N">stroke</Keyword><Keyword MajorTopicYN="N">vertigo</Keyword><Keyword MajorTopicYN="N">video-oculography</Keyword></KeywordList><CoiStatement>Competing interests: None declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>6</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29018076</ArticleId><ArticleId IdType="pii">bmjopen-2017-019073</ArticleId><ArticleId IdType="doi">10.1136/bmjopen-2017-019073</ArticleId><ArticleId IdType="pmc">PMC5652468</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Neurol Sci. 2006 Nov 15;249(2):172-4</Citation><ArticleIdList><ArticleId IdType="pubmed">16843496</ArticleId></ArticleIdList></Reference><Reference><Citation>Stroke. 2012 Jun;43(6):1484-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22442167</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurology. 2008 Jun 10;70(24 Pt 2):2378-85</Citation><ArticleIdList><ArticleId 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last="Jahn">Klaus Jahn</name><name sortKey="Muller, Hans Helge" sort="Muller, Hans Helge" uniqKey="Muller H" first="Hans-Helge" last="Müller">Hans-Helge Müller</name><name sortKey="Zwergal, Andreas" sort="Zwergal, Andreas" uniqKey="Zwergal A" first="Andreas" last="Zwergal">Andreas Zwergal</name><name sortKey="Zwergal, Andreas" sort="Zwergal, Andreas" uniqKey="Zwergal A" first="Andreas" last="Zwergal">Andreas Zwergal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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